Greg Bundy, AIMS Financial Group, discusses opportunities in the multinational companies, particularly in Japan and China.
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Spotify
By Rosa Golijan
The folks behind?popular music streaming service Spotify?have some "exciting news" to share on November 30?? or at least so an invitation to their press conference tells us.
The invitation is pretty slim on details. We know that the event's theme is "what's next for Spotify" and that it?will be?hosted by the company's?co-founder and CEO Daniel Ek (as well as "a special guest or two").
Anything beyond those details is pure speculation.
Is Spotify planning to?begin allowing U.S.-based customers to purchase songs directly through the service (as Europe-based users may already do)? Will there be a snazzy new set of mobile apps? Has the company finally figured out a way to cure my addiction to horrible pop music?
We'll have to wait until November 30 to find out.
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Want more tech news, silly puns, or amusing links? You'll get plenty of all three if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts, or circling her?on?Google+.
Source: http://technolog.msnbc.msn.com/_news/2011/11/21/8931178-spotify-to-announce-whats-next-on-nov-30
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Rihanna And Her Vagina Don’t Enjoy Being Single (VIDEO)
Singer Rihanna opened up on “The Ellen DeGeneres Show” on her single status, saying she doesn’t really enjoy living the single life. Rihanna, who was [...]
Rihanna And Her Vagina Don’t Enjoy Being Single (VIDEO) Stupid Celebrities Gossip Stupid Celebrities Gossip News
Source: http://stupidcelebrities.net/2011/11/20/rihanna-and-her-vagina-dont-enjoy-being-single-video/
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'We Found Love,' 'Watch n' Learn' define singer's sixth album.
By Jocelyn Vena
Rihanna
Photo: Ian Gavan/ Getty Images
Rihanna's Talk That Talk might be the defining party album of 2011. Released Monday (November 21), the singer's sixth studio album in nearly as many years is the kind of record a DJ can play straight through at a club, filled with pulsing bangers about all things sexy.
To say the least, it's not an album for those who easily blush. It's hard, grinding and aggressive. Rihanna uses the type of saucy language not often heard on mainstream pop records. Rounding up a slew of A-listers including Calvin Harris, Dr. Luke, Stargate, The-Dream, Ester Dean and No I.D., Rihanna put together a cohesive record about how hot love can get between the sheets.
MTV News' picks for Talk That Talk's five key tracks:
"We Found Love"
One of two Calvin Harris collaborations (the other is the equally club-stomping "Where Have You Been"), "We Found Love" defines this era for the singer, whose album is heavily influenced by dance music and club culture. "WFL" is so big and infectious that it's hard to ignore the strength of this track.
"Cockiness"
Perhaps the most swagged-out track on all of TTT, "Cockiness" is a no-holds-barred, full-throttle song. Produced by Bangladesh, Rihanna relays absolutely everything she wants her man to do once they manage to sneak away and get it on. Full of sirens, thumping beats, tempo changes and sampled noises, "Cockiness" is raunchy — the kind of raunchy you want to dance the night away to.
"Talk That Talk"
Joined by her mentor Jay-Z (who lyrically struts over this track like it's still the "Umbrella" days), this Stargate-produced track is classic Rihanna. Big and hard with just enough brightness, it's the type of song that can get played on both Urban and Top 40 stations. Where "Cockiness" was brazen, "Talk That Talk" allows the sex to live in a place that feels less NSFW.
"Roc Me Out"
Rarely is Rihanna vulnerable on this album, and rarely would that happen on an uptempo jam. On this Stargate track (the third of three), Rihanna displays her signature bravado, but hidden in there is one deep insight into who Ri is on the inside when she confesses, "Take a peek at the girl I hide/ I'll let you in on a dirty secret/ I just wanna be loved."
"Watch n' Learn"
A sort of how-to guide, the playful Hit-Boy track "Watch n' Learn" is all about Ri teaching her man how to love her just the right way. The lyrics are quite sassy, but the melody is just soft enough to make you forget that the track is actually kind of dirty.
What's your favorite Talk That Talk track? Tell us in the comments!
Related ArtistsSource: http://www.mtv.com/news/articles/1674711/rihanna-talk-that-talk-tracks.jhtml
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Some of the ways bacteria protect themselves from antibiotics might be used against them to strengthen existing drugs
?| November 18, 2011?|
Shutting out a killer: This Pseudomonas aeruginosa infection activates a stress response that allows it to tolerate antibiotic attacks.
Image: Torsten Bernhardt
The superbug MRSA has provoked fear in doctors and patients alike because it is endowed with genetic characteristics that make it impervious to many antibiotics, and it can be deadly to boot. Less well known, however, is another class of bacteria that also resist antibiotics, but for reasons that have puzzled scientists. These bugs cause stubborn infections in ears and urinary tracts and post-surgical wounds, even though, from their genetic profiles, they should be perfectly good targets for antibiotics.
Researchers are now starting to figure out how these bacteria withstand treatment from antibiotics: by exploiting the same traits that have helped them endure environmental stressors. Two new research papers, published Friday in Science, show how bacteria use their ability to withstand prolonged periods without food and reactive oxygen to fight off antibiotics. Knowing what these defenses are could lead to new ways of making existing antibiotics more effective.
Scientists do not yet fully understand how antibiotics work on a molecular level, but they think that the drugs are effective in part by introducing reactive oxygen to bacterial cells, which damages key cellular structures.
Evgeny Nudler, a biochemist at the New York University School of Medicine, and his colleagues have unraveled details about how bacteria protect themselves from such "oxidative stress." They produce hydrogen sulfide, which, in combination with nitric oxide, a typical by-product of bacterial metabolism, seems to protect bacteria from antibiotic assaults. Nudler?s team found three enzymes that are responsible for triggering the production of this gas in Staphylococcus aureus, Escherichia coli and other bacteria. "It was a major surprise," he says. "If you treat cells with antibiotics, you see that they start producing more [hydrogen sulfide] right away."
Bacteria that are starved for nutrients can also turn their weakened state to their advantage in warding off antibiotics, according to the second paper.? Scientists have known that bacteria that are starved for nutrients are better able to resist the chemical blows dealt by antibiotics. This reaction, known as stringent response, is common across bacterial species. The question was whether the bacteria were just hunkering down when faced with low levels of nutrients or were more actively defending themselves.
Dao Nguyen, a microbiologist at McGill University, and her colleagues investigated the behavior of strains of Pseudomonas aeruginosa, a relatively common bug that can cause infections in the urinary tract, kidneys or lungs,that were isolated from patients who had chronic infections. They found that when the bacteria were not getting enough nutrients, they showed signs of a so-called stringent response. "As the bacteria sense starvation? [they] produce an alarm signal called (p)ppGpp," Nguyen explained in a Science podcast. "And this allows the cells to regulate a vast number of genes, which then allows it to better adapt and survive in response to starvation and stress."
To test whether this stringent response could also be protecting the bacteria from antibiotics, the researchers created a mutant strain that lacked such an alarm. Indeed, antibiotics were much more effective against those bacteria strains that could not turn on their stringent response. The pattern held up in mice as well. When mice infected with bacteria lacking a stringent response were given antibiotics, their infections cleared up and the mice survived. "With normal, wild type bacteria, the mice would die even if you treated them with the antibiotics," Nguyen said in the podcast.
Altering antibiotics
Researchers are still learning more about just how, molecularly, these different responses are triggered. "These studies together show that bacteria have clever antioxidant strategies to counter the oxidative damage generated by antibiotics," notes James Collins, an investigator at the Howard Hughes Medical Institute, who also co-authored an essay about the two new papers in the same issue of Science. Both of the research teams suggest ways in which these newly described mechanisms could boost the strength of drugs we already have.
"Perhaps you could find a way to exploit this starvation response in such a way that if you disrupt the stringent response somehow, you could sensitize the bacteria to currently available antibiotics," Nguyen said. And if the enzymes that trigger the bacteria's creation of protective hydrogen sulfide in Nudler's study could be disabled, the bugs could be rendered more susceptible to drugs. He and his team are using high-throughput screening to find small molecules to inhibit the enzymes. They have already found a couple candidates that seem capable of taking out one of the enzymes.
But just learning more about the complexity of these well adapted bacteria, also suggests that, "our battles with bugs may be tougher than we thought," Collins cautions.
Source: http://rss.sciam.com/click.phdo?i=310af3de827ef6475133c5c04c60dc21
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POSTED: 11:00 pm EST November 17, 2011
UPDATED: 6:58 am EST November 18, 2011
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Source: http://www.wbaltv.com/news/29800605/detail.html
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